منابع مشابه
Targeted Therapies in Melanoma: Successes and Pitfalls
Incidence of melanoma is steadily rising worldwide [1]. Lifetime risk of developing melano‐ ma in Caucasians is estimated as 1 in 50 individuals [2-3]. The incidence of melanoma varies according to the geographical origins of the population and the extent of sun exposure. In Australia and United States, an incidence of melanoma higher than observed in the Europe‐ an countries (with the notable ...
متن کاملMolecular targeted therapies in metastatic melanoma
The advent of personalized medicine has ushered in a new era for cancer therapy with a significant impact on the management of advanced melanoma. Molecular targeted therapies have shown promise in the management of various malignancies, including melanoma, with lower toxicity profiles and better overall survival as compared with conventional therapy. The discovery of BRAF mutations in melanoma ...
متن کاملEmerging targeted therapies for melanoma treatment (Review)
Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development of novel therapies for this devastating disease. In melanoma, both the Ras/Raf/MEK/ERK (MAPK) and the PI3K/AKT (AKT) signalling pathways are constitutively activated through...
متن کاملMelanoma Metastasis and New Targeted Therapies
Melanoma is the deadliest form of skin cancer. Melanoma develops in response to genetic and environmental pressures which lead to oncogenic transformation of normal human melanocytes, the pigment-producing cells in the body. The majority of melanoma-associated deaths are due to metastases, highlighting the importance of understanding the molecular mechanisms driving melanoma development and pro...
متن کاملTargeted Therapies for Melanoma Brain Metastases
OPINION STATEMENT Brain metastases are a major clinical challenge occurring in up to 60% of patients suffering from metastatic melanoma. They cause significant clinical symptoms and impair the overall survival prognosis. The introduction of targeted therapies including BRAF and MEK inhibitors as well as CTLA-4 and PD-1 axis targeting immune checkpoint inhibitors have dramatically improved the t...
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ژورنال
عنوان ژورنال: Surgical Oncology Clinics of North America
سال: 2015
ISSN: 1055-3207
DOI: 10.1016/j.soc.2014.12.011